No, if the same taxpayer continues to operate at the same location where the Retail License was registered (unless the Retail License is revoked by the SCDOR).
Yes, if the ownership of the business changes, making the pervious owner's Retail License invalid. The new owner would need to apply for a new Retail License in their name.
If you have not made sales for 24 consecutive months, South Carolina law requires a taxpayer to surrender their Retail License.