If you plan to make sales in South Carolina, you likely need a Retail License.
The SCDOR also issues other licenses that may be required depending on your business type and what you sell. This page provides licensing information for selling goods or services taxed under:
A Retail License is not the same as a business license, which is issued by the county where you conduct business, if required by that county. Still not sure what you are looking for? Check out South Carolina Business One Stop to help you get started!